InterPro domain: IPR037679

Apc5 is a subunit of the eukaryotic anaphase-promoting complex/cyclosome (APC/C) which is a multi-subunit ubiquitin ligase that mediates the proteolysis of cell cycle proteins in mitosis and G1. Although Apc5 does not contain a classical RNA binding domain, it binds the poly(A) binding protein (PABP), which directly binds the internal ribosome entry site (IRES) of growth factor 2 mRNA [ 1 ].

This entry also includes two Apc5 paralogues from C. elegans: such-1 and gfi-3. They are coexpressed in the germline but have nonoverlapping expression patterns in other tissues. They have a redundant function during the meiotic divisions [ 2 ].

1. The Apc5 subunit of the anaphase-promoting complex/cyclosome interacts with poly(A) binding protein and represses internal ribosome entry site-mediated translation. Mol. Cell. Biol. 24, 3577-87
2. Functional redundancy of paralogs of an anaphase promoting complex/cyclosome subunit in Caenorhabditis elegans meiosis. Genetics 186, 1285-93