InterPro domain: IPR037637
General Information
- Identifier IPR037637
- Description Nuclear pore complex protein NUP98-NUP96
- Number of genes 242
- Gene duplication stats Loading...
- Associated GO terms GO:0017056
Abstract
The entry includes components of the nuclear pore complex (NPC), which is required for transport of macromolecules in and out of the nucleus. These components are all nucleoporins. Components Nup98 and Nup96 are products of autolytic processing of a precursor protein that is effectively a serine endopeptidase (MEROPS identifier S59.001). The precursor is known as Nup189 in Schizosaccharomyces pombe. This entry also includes nucleoporin Nup100 from Saccharomyces cerevisiae, which does not process itself but which is important for poly(A)+ RNA and protein transport. Nup100 has a tetrapeptide glycine-leucine-phenylalanine-glycine (GLFG) motif where it binds karyopherin transport factor Kap95p [ 1 ].
1. The GLFG regions of Nup116p and Nup100p serve as binding sites for both Kap95p and Mex67p at the nuclear pore complex. J. Biol. Chem. 276, 6445-52