InterPro domain: IPR036561

This mitochondrial matrix protein superfamily contains members of the MAM33 superfamily which bind to the globular 'heads' of C1Q.b. It is thought to be involved in mitochondrial oxidative phosphorylation and in nucleus-mitochondrion interactions [ 1 , 2 , 3 ]. Its structure consists of an beta(7)-alpha(2) fold with N- and C-terminal extensions forming a coiled coil subdomain.

1. Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein. Proc. Natl. Acad. Sci. U.S.A. 96, 3572-7
2. Mam33p, an oligomeric, acidic protein in the mitochondrial matrix of Saccharomyces cerevisiae is related to the human complement receptor gC1q-R. Yeast 14, 303-10
3. Crystal structures and putative interface of Saccharomyces cerevisiae mitochondrial matrix proteins Mmf1 and Mam33. J. Struct. Biol. 175, 469-74