InterPro domain: IPR036546

General Information

  • Identifier IPR036546
  • Description Mediator complex subunit 15, KIX domain
  • Number of genes 509
  • Gene duplication stats Loading...

Abstract

GAL11 is a component of the Mediator complex, a co-activator that plays critical roles in transcriptional activation. The GAL11/MED15 subunit has an N-terminal KIX domain, which is an activator-binding domain. This domain contains a docking site for the activation domain of yeast drug resistance protein Pdr1, therefore is thought to be involved in antifungal/xenobiotic-dependent regulation of multidrug resistance [ 1 ].


1. A nuclear receptor-like pathway regulating multidrug resistance in fungi. Nature 452, 604-9

Species distribution

Gene table