InterPro domain: IPR034741

Enzymes in this subgroup generally have two domains, with the C-terminal domain being a member of this subgroup and the N-terminal domain being a member of the terpene cyclase-like 1 N-terminal subgroup in the isoprenoid synthase class II superfamily. It has been suggested that this gene family be designated tps (for terpene synthase). Sequence comparisons reveal similarities between the monoterpene (C10) synthases, sesquiterpene (C15) synthases and the diterpene (C20) synthases. It has been split into six subgroups on the basis of phylogeny, called Tpsa-Tpsg [ 1 , 2 , 3 , 4 ].

1. Monoterpene synthases from grand fir (Abies grandis). cDNA isolation, characterization, and functional expression of myrcene synthase, (-)-(4S)-limonene synthase, and (-)-(1S,5S)-pinene synthase. J. Biol. Chem. 272, 21784-92
2. Structural biology and chemistry of the terpenoid cyclases. Chem. Rev. 106, 3412-42
3. Terpene biosynthesis: modularity rules. Angew. Chem. Int. Ed. Engl. 51, 1124-37
4. Functional characterization of nine Norway Spruce TPS genes and evolution of gymnosperm terpene synthases of the TPS-d subfamily. Plant Physiol. 135, 1908-27