InterPro domain: IPR034003

This entry represents the second domain of the pleiotropic drug resistance-like subfamily G of ATP-binding cassette (ABC) transporters.

Pleiotropic drug resistance (PDR) is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes [ 1 ]. This PDR subfamily represents domain II of its (ABC-IM)2 organization. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and more complex organic molecules [ 2 ]. The nucleotide binding domain shows the highest similarity between all members of the family [ 3 ]. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins [ 4 ], [ 4 ].

1. The plant PDR family of ABC transporters. Planta 216, 95-106
2. ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans. J. Mol. Biol. 293, 381-99
3. A common mechanism for ATP hydrolysis in ABC transporter and helicase superfamilies. Trends Biochem. Sci. 26, 539-44
4. The human ATP-binding cassette (ABC) transporter superfamily. Genome Res. 11, 1156-66