InterPro domain: IPR033896
General Information
- Identifier IPR033896
- Description MADS MEF2-like
- Number of genes 4527
- Gene duplication stats Loading...
- Associated GO terms GO:0000977 GO:0045944
Abstract
This entry represents the MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor)) box family of eukaryotic transcriptional regulators [ 1 ]. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface [ 2 ]. Important in homeotic regulation in plants and in immediate-early development in animals [ 3 ]. Also found in fungi [ 4 ].
1. The MADS-box family of transcription factors. Eur. J. Biochem. 229, 1-13
2. Solution structure of the MEF2A-DNA complex: structural basis for the modulation of DNA bending and specificity by MADS-box transcription factors. EMBO J. 19, 2615-28
3. An ancestral MADS-box gene duplication occurred before the divergence of plants and animals. Proc. Natl. Acad. Sci. U.S.A. 97, 5328-33
4. Classification and phylogeny of the MADS-box multigene family suggest defined roles of MADS-box gene subfamilies in the morphological evolution of eukaryotes. J. Mol. Evol. 43, 484-516