InterPro domain: IPR033825

General Information

  • Identifier IPR033825
  • Description FACT complex subunit Spt16, peptidase M24-like domain
  • Number of genes 199
  • Gene duplication stats Loading...

Abstract

Spt6 (also known as cdc68) is a component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes [ 1 , 2 , 3 ]. Spt16 is a non-peptidase homologue in peptidase family M24 [ 4 ].


1. A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. Mol. Cell 7, 283-92
2. Mutations in SPT16/CDC68 suppress cis- and trans-acting mutations that affect promoter function in Saccharomyces cerevisiae. Mol. Cell. Biol. 11, 5710-7
3. CDC68, a yeast gene that affects regulation of cell proliferation and transcription, encodes a protein with a highly acidic carboxyl terminus. Mol. Cell. Biol. 11, 5718-26
4. Evolutionary families of metallopeptidases. Meth. Enzymol. 248, 183-228

Species distribution

Gene table