InterPro domain: IPR033489
General Information
- Identifier IPR033489
- Description E3 ubiquitin-protein ligase RBBP6 family
- Number of genes 348
- Gene duplication stats Loading...
- Associated GO terms GO:0061630 GO:0006397 GO:0016567
Abstract
RBBP6 interacts with both p53 and pRb and has been implicated in mRNA processing [ 1 ]. It also acts as a E3 ubiquitin-protein ligase that interacts with YB-1 and ZBTB38, leading to ubiquitination of both proteins [ 2 , 3 ]. It is involved in regulating DNA replication and common fragile site stability [ 4 ].
This family also includes the homologues from yeast Mpe1 [ 4 ] and PARAQUAT TOLERANCE3 from Arabidopsis [ 5 ].
1. RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3' UTRs. Genes Dev. 28, 2248-60
2. RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1. J. Mol. Biol. 384, 908-16
3. The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability. Cell Rep 7, 575-87
4. Efficient mRNA polyadenylation requires a ubiquitin-like domain, a zinc knuckle, and a RING finger domain, all contained in the Mpe1 protein. Mol. Cell. Biol. 34, 3955-67
5. PARAQUAT TOLERANCE3 Is an E3 Ligase That Switches off Activated Oxidative Response by Targeting Histone-Modifying PROTEIN METHYLTRANSFERASE4b. PLoS Genet. 12, e1006332