InterPro domain: IPR033173

Gcn1 acts as a translation activator that mediates translational control by regulating Gcn2 kinase activity. The eIF2alpha kinase Gcn2 is activated under stress conditions by a mechanism involving Gcn2 binding to activator protein Gcn1 [ 1 , 2 ]. Phosphorylation of eIF2alpha results in general protein synthesis repression and increased translation of specific mRNAs. Protein ILITYHIA from Arabidopsis is involved in immunity against bacterial infection and in non-host resistance [ 3 ] and is required for the bacterium-triggered stomatal closure response [ 4 ].

1. Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2. Biochem. Biophys. Res. Commun. 443, 592-7
2. Gcn1 contacts the small ribosomal protein Rps10, which is required for full activation of the protein kinase Gcn2. Biochem. J. 466, 547-59
3. Genetic subtraction profiling identifies genes essential for Arabidopsis reproduction and reveals interaction between the female gametophyte and the maternal sporophyte. Genome Biol. 8, R204
4. A genetic screen reveals Arabidopsis stomatal and/or apoplastic defenses against Pseudomonas syringae pv. tomato DC3000. PLoS Pathog. 7, e1002291