InterPro domain: IPR032801
General Information
- Identifier IPR032801
- Description Peroxiredoxin-like 2A/B/C
- Number of genes 385
- Gene duplication stats Loading...
Abstract
This family consists of proteins from the peroxiredoxin-like family, including PRXL2A, PXL2B (also known as prostamide/prostaglandin F synthase) [ 1 ] and PXL2C (also known as AAED1). PRXL2A is a secreted redox regulatory protein with potent anti-inflammatory properties [ 2 ]. PXL2C regulates proliferation and glycolysis in gastric cancer [ 3 ].
1. Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily. J. Biol. Chem. 283, 792-801
2. Adipocyte-derived PAMM suppresses macrophage inflammation by inhibiting MAPK signalling. Biochem. J. 472, 309-18
3. AAED1 modulates proliferation and glycolysis in gastric cancer. Oncol. Rep. 40, 1156-1164
Species distribution
Gene table
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