InterPro domain: IPR032801

This family consists of proteins from the peroxiredoxin-like family, including PRXL2A, PXL2B (also known as prostamide/prostaglandin F synthase) [ 1 ] and PXL2C (also known as AAED1). PRXL2A is a secreted redox regulatory protein with potent anti-inflammatory properties [ 2 ]. PXL2C regulates proliferation and glycolysis in gastric cancer [ 3 ].

1. Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily. J. Biol. Chem. 283, 792-801
2. Adipocyte-derived PAMM suppresses macrophage inflammation by inhibiting MAPK signalling. Biochem. J. 472, 309-18
3. AAED1 modulates proliferation and glycolysis in gastric cancer. Oncol. Rep. 40, 1156-1164