InterPro domain: IPR032076

General Information

  • Identifier IPR032076
  • Description Tetratricopeptide repeat protein 5, OB fold domain
  • Number of genes 111
  • Gene duplication stats Loading...

Abstract

This OB fold domain is located at the C terminus of tetratricopeptide repeat protein 5 (TTC5) and is required for effective p53 response [ 1 ]. TTC5 can activate the p53 pathway and inhibit AP-1 transcriptional activity [ 2 ].


1. The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure. Proc. Natl. Acad. Sci. U.S.A. 109, 3778-83
2. Human TTC5, a novel tetratricopeptide repeat domain containing gene, activates p53 and inhibits AP-1 pathway. Mol. Biol. Rep. 40, 6183-8

Species distribution

Gene table