InterPro domain: IPR029710
General Information
- Identifier IPR029710
- Description DNA ligase 4
- Number of genes 146
- Gene duplication stats Loading...
- Associated GO terms GO:0051103 GO:0003677 GO:0005524 GO:0006281 GO:0003910
Abstract
DNA ligase 4 (LIG4) is involved in DNA double-strand break repair [ 1 ]. In higher eukaryotes it forms a complex with XRCC4, which is responsible for the ligation step during the DNA-PK-dependent non-homologous end joining (D-NHEJ) [ 2 , 3 ]. The Ku component of the DNA-PK (DNA-dependent protein kinase) complex contributes to the recruitment of the LIG4-XRCC4 complex at the DNA break site [ 4 ].
1. Ku80- and DNA ligase IV-deficient plants are sensitive to ionizing radiation and defective in T-DNA integration. Plant J. 34, 427-40
2. Backup pathways of NHEJ in cells of higher eukaryotes: cell cycle dependence. Radiother Oncol 92, 310-5
3. Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells. Nucleic Acids Res. 29, 1653-60