InterPro domain: IPR028598
General Information
- Identifier IPR028598
- Description WD repeat BOP1/Erb1
- Number of genes 164
- Gene duplication stats Loading...
- Associated GO terms GO:0042254
Abstract
This entry represents the WD repeat BOP1/Erb1 family. Members of this family are ribosome biogenesis proteins.
In humans and mice, BOP1 is a component of the PeBoW complex (composed of BOP1, PES1 and WDR12), which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome [ 1 ].
In Saccharomyces cerevisiae, Erb1 is a component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome [ 2 ].
1. Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. Mol. Cell. Biol. 27, 3682-94
2. Interactions among Ytm1, Erb1, and Nop7 required for assembly of the Nop7-subcomplex in yeast preribosomes. Mol. Biol. Cell 19, 2844-56