InterPro domain: IPR028288

General Information

  • Identifier IPR028288
  • Description SCAR/WAVE family
  • Number of genes 385
  • Gene duplication stats Loading...
  • Associated GO terms GO:0005856   GO:0030036  

Abstract

This entry represents the SCAR/WAVE family. Members in this family include Wiskott-Aldrich syndrome protein family members 1-3 (WAVE 1-3), protein SCAR 1-4, protein WAVE5 and SCAR-like proteins.

SCAR/WAVE family members are downstream effector molecules receiving information from multiple signalling pathways and responding by promoting the actin nucleating activity of the ubiquitous Arp2/3 complex [ 1 ]. They are part of the WAVE complex that regulates lamellipodia formation in animals and maintains cell shape in plants [ 2 , 2 ].


1. Structure and control of the actin regulatory WAVE complex. Nature 468, 533-8
2. ARP2/3-dependent growth in the plant kingdom: SCARs for life. Front Plant Sci 4, 166

Species distribution

Gene table