InterPro domain: IPR026741
General Information
- Identifier IPR026741
- Description Protein strawberry notch
- Number of genes 208
- Gene duplication stats Loading...
- Associated GO terms GO:0006355
Abstract
Strawberry notch proteins carry DExD/H-box groups and helicase C-terminal domains. These proteins promote the expression of diverse targets, potentially through interactions with transcriptional activator or repressor complexes [ 1 ]. Strawberry notch was first identified in Drosophila where functions downstream of Notch and regulates gene expression during development [ 2 , 3 ].
Protein FORGETTER 1 (included in this entry) is the A. thaliana orthologue of Strawberry notch [ 4 ].
1. A strawberry notch homolog, let-765/nsh-1, positively regulates lin-3/egf expression to promote RAS-dependent vulval induction in C. elegans. Dev. Biol. 341, 472-85
2. strawberry notch encodes a conserved nuclear protein that functions downstream of Notch and regulates gene expression along the developing wing margin of Drosophila. Genes Dev. 11, 1341-53
3. Developmental signaling: shrimp and strawberries help flies make cones. Curr. Biol. 12, R722-4
4. Arabidopsis FORGETTER1 mediates stress-induced chromatin memory through nucleosome remodeling. Elife 5