InterPro domain: IPR025829

This is a zinc-binding domain of the form CxxCxxxGHxxxxC from a variety of different species. It is found in the MPE1 protein from Saccharomyces cerevisiae which is a component of the cleavage and polyadenylation factor (CPF) complex important for polyadenylation-dependent pre-mRNA 3'-end formation [ 1 ].

1. Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends. J. Biol. Chem. 278, 33000-10