InterPro domain: IPR024166

This group represents ribosomal RNA assembly protein KRR1, required for 40S ribosome biogenesis. It is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly in Saccharomyces cerevisiae [ 1 , 2 ]. In Schizosaccharomyces pombe it is known as Mis3 [ 3 ].

1. The KRR1 gene encodes a protein required for 18S rRNA synthesis and 40S ribosomal subunit assembly in Saccharomyces cerevisiae. Acta Biochim. Pol. 47, 993-1005
2. Functional and physical interactions of Krr1p, a Saccharomyces cerevisiae nucleolar protein. Acta Biochim. Pol. 51, 173-87
3. Mis3 with a conserved RNA binding motif is essential for ribosome biogenesis and implicated in the start of cell growth and S phase checkpoint. Genes Cells 5, 525-41