InterPro domain: IPR021827
General Information
- Identifier IPR021827
- Description Nucleoporin Nup186/Nup192/Nup205
- Number of genes 626
- Gene duplication stats Loading...
- Associated GO terms GO:0005643
Abstract
Proteins in this family are components of the nuclear pore complex (NPC). These protein are called nucleoporins (NUPs), which can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. This entry includes Nup186/Nup192/Nup205. In budding yeasts, Nup192 is located to the NPC core at the nuclear membrane and is essential for de novo assembly of NPCs [ 1 ]. In humans, Nup205 forms a complex with NUP53, NUP93, NUP155 and lamin B [ 2 ].
1. Nup192p is a conserved nucleoporin with a preferential location at the inner site of the nuclear membrane. J. Biol. Chem. 274, 22646-51
2. Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. Mol. Biol. Cell 16, 2382-94