InterPro domain: IPR018982
General Information
- Identifier IPR018982
- Description RQC domain
- Number of genes 289
- Gene duplication stats Loading...
- Associated GO terms GO:0006281 GO:0006260 GO:0043138
Abstract
This entry represents the RQC domain, which is a DNA-binding domain found only in RecQ family enzymes. RecQ family helicases can unwind G4 DNA, and play important roles at G-rich domains of the genome, including the telomeres, rDNA, and immunoglobulin switch regions. This domain has a helix-turn-helix structure and acts as a high affinity G4 DNA binding domain [ 1 ]. Binding of RecQ to Holliday junctions involves both the RQC and the HRDC domains.
1. A conserved G4 DNA binding domain in RecQ family helicases. J. Mol. Biol. 358, 1071-80
Species distribution
Gene table
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