InterPro domain: IPR018834

General Information

  • Identifier IPR018834
  • Description DNA/RNA-binding domain, Est1-type
  • Number of genes 339
  • Gene duplication stats Loading...

Abstract

This entry represents a DNA/RNA binding domain found in the telomere elongation protein EST1 and related sequences, such as the nonsense-mediated mRNA decay pathway proteins SMG5 and SMG7 [ 1 , 2 , 3 ].


1. Telomere maintenance in fission yeast requires an Est1 ortholog. Curr. Biol. 13, 575-80
2. Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol. Cell 12, 1187-200
3. SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. Mol. Cell 16, 587-96

Species distribution

Gene table