InterPro domain: IPR016964

Sigma-2 receptor, also known as TMEM97, is an intracellular orphan receptor highly expressed in various rapidly proliferating cancer cells and regarded as a cancer cell biomarker. It is a cytochrome-related protein that binds to various pharmacological compounds, and modulates the cytosolic Ca2+ concentration, dopaminergic transmission, and cocaine-induced addiction behavior [ 1 , 2 , 3 ]. It may have a role as regulator of cellular cholesterol homeostasis [ 4 ] and function as a sterol isomerase [ 5 ].

1. Sigma-2 receptor ligands and their perspectives in cancer diagnosis and therapy. Med Res Rev 34, 532-66
2. S2R(Pgrmc1): the cytochrome-related sigma-2 receptor that regulates lipid and drug metabolism and hormone signaling. Expert Opin Drug Metab Toxicol 8, 361-70
3. Sigma-2 receptor ligands: neurobiological effects. Curr. Med. Chem. 22, 989-1003
4. Identification of cholesterol-regulating genes by targeted RNAi screening. Cell Metab. 10, 63-75
5. TM6SF2 and MAC30, new enzyme homologs in sterol metabolism and common metabolic disease. Front Genet 5, 439