InterPro domain: IPR016135

This superfamily represents a structural domain with an alpha-beta(4)-alpha(3) core fold. Domains of this structure are found in:

• Ubiquitin conjugating enzyme E2, as well as related proteins such as ubiquitin carrier protein 4 and ubiquitin-protein ligase W [ 1 ].
• The UEV domain in tumour susceptibility gene 101 [ 2 ] and vacuolar protein sorting-associated protein [ 3 ].
• RWD domain, found in RING finger and WD repeat-containing proteins, such as EIF-2 kinase 4 (GCN2-like protein) [ 4 ].
• UFC1-like domain found in Ufm1-conjugating enzyme 1 [ 5 ].

1. The NMR structure of the class I human ubiquitin-conjugating enzyme 2b. J. Biomol. NMR 22, 89-92
2. Structure of human TSG101 UEV domain. Acta Crystallogr. D Biol. Crystallogr. 62, 458-64
3. Structural insights into endosomal sorting complex required for transport (ESCRT-I) recognition of ubiquitinated proteins. J. Biol. Chem. 279, 28689-96
4. Solution structure of the RWD domain of the mouse GCN2 protein. Protein Sci. 13, 2089-100
5. Crystal structure of Ufc1, the Ufm1-conjugating enzyme. Biochem. Biophys. Res. Commun. 362, 1079-84