InterPro domain: IPR016035

This superfamily represents a structural domain with a 3-layer alpha/beta/alpha topology. This domain can be found in acyl transferases such as bacterial malonyl-CoA ACP transacylase (FabD) and the homologous domain from eukaryotic fatty acid synthase [ 1 ]. This domain is also found in lysophospholipases such as cytosolic phospholipase A2 (which has additional structural features) [ 2 ], and in patatin proteins, which are plant glycoproteins that act as non-specific lipid acyl hydrolases [ 3 ].

1. Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase. Structure 11, 147-54
2. Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism. Cell 97, 349-60
3. The crystal structure, mutagenesis, and activity studies reveal that patatin is a lipid acyl hydrolase with a Ser-Asp catalytic dyad. Biochemistry 42, 6696-708