InterPro domain: IPR014729

This superfamily represents domains related by a common ancestor that have a Rossmann-like, 3-layer, alpha/beta/alpha sandwich fold. Protein families in which the domain is found include:

• Nucleotidylyl transferases ( 2.7.7 ) such as cytidylyltransferases [ 1 ], adenylyltransferases [ 2 ].
• Class I aminoacyl-tRNA synthetases (catalytic domain), such as tyrosyl-tRNA synthetase ( 6.1.1.1 ) and glutaminyl-tRNA synthetase ( 6.1.1.18 ) [ 3 ].
• Pantothenate synthetases ( 6.3.2.1 ) [ 4 ].
• ATP sulphurylase (central domain) [ 5 ]
• N-type ATP pyrophosphatases, such as beta-lactam synthetase ( 6.3.3.4 ) and GMP synthase ( 6.3.5.2 ) [ 6 ].
• PP-loop ATPases such as the cell cycle protein MesJ (N-terminal domain) [ 7 ].
• Phosphoadenylyl sulphate (PAPS) reductase [ 8 ]
• Electron transfer flavoprotein (ETFP) subunits, such as the N-terminal domains of the alpha and beta subunits [ 9 ].
• Universal stress protein A (UspA) [ 10 ].
• Cryptochrome and DNA photolyase [ 11 ].

1. Crystal structure of CTP:glycerol-3-phosphate cytidylyltransferase from Staphylococcus aureus: examination of structural basis for kinetic mechanism. Biochim. Biophys. Acta 1764, 63-9
2. Structure and implications for the thermal stability of phosphopantetheine adenylyltransferase from Thermus thermophilus. Acta Crystallogr. D Biol. Crystallogr. 60, 97-104
3. Architectures of class-defining and specific domains of glutamyl-tRNA synthetase. Science 267, 1958-65
4. Crystal structure of the pantothenate synthetase from Mycobacterium tuberculosis, snapshots of the enzyme in action. Biochemistry 45, 1554-61
5. Molecular basis for G protein control of the prokaryotic ATP sulfurylase. Mol. Cell 21, 109-22
6. The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families. Nat. Struct. Biol. 3, 74-86
7. Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain. Proc. Natl. Acad. Sci. U.S.A. 102, 7487-92
8. Crystal structure of phosphoadenylyl sulphate (PAPS) reductase: a new family of adenine nucleotide alpha hydrolases. Structure 5, 895-906
9. Three-dimensional structure of human electron transfer flavoprotein to 2.1-A resolution. Proc. Natl. Acad. Sci. U.S.A. 93, 14355-60
10. The Pseudomonas aeruginosa universal stress protein PA4352 is essential for surviving anaerobic energy stress. J. Bacteriol. 188, 6529-38
11. Crystal structure of cryptochrome 3 from Arabidopsis thaliana and its implications for photolyase activity. Proc. Natl. Acad. Sci. U.S.A. 103, 17701-6