InterPro domain: IPR013956

General Information

  • Identifier IPR013956
  • Description E3 ubiquitin ligase Bre1
  • Number of genes 279
  • Gene duplication stats Loading...
  • Associated GO terms GO:0004842   GO:0010390  

Abstract

Bre1 is an E3 ubiquitin ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1 in association with the E2 enzyme Rad6/Ubc2 [ 1 ].

This entry also includes Bre1 homologues from fission yeasts, Brl1 and Brl2. They are E3 ubiquitin-protein ligase components of the multisubunit protein complex (termed HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1 [ 2 ].


1. Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Mol. Cell 11, 267-74
2. HULC, a histone H2B ubiquitinating complex, modulates heterochromatin independent of histone methylation in fission yeast. J. Biol. Chem. 282, 14065-72

Species distribution

Gene table