InterPro domain: IPR013520

This entry includes a variety of exonuclease proteins, such as ribonuclease T [ 1 ] and the epsilon subunit of DNA polymerase III. Ribonuclease T is responsible for the end-turnover of tRNA,and removes the terminal AMP residue from uncharged tRNA. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria, and also exhibits 3' to 5' exonuclease activity.

1. RNase T shares conserved sequence motifs with DNA proofreading exonucleases. Nucleic Acids Res. 21, 2521-2