InterPro domain: IPR013154

This is the catalytic domain of alcohol dehydrogenases ( 1.1.1.1 ). Many of them contain an inserted zinc binding domain. This domain has a GroES-like structure; a name derived from the superfamily of proteins with a GroES fold. Proteins with a GroES fold structure have a highly conserved hydrophobic core and a glycyl-aspartate dipeptide which is thought to maintain the fold [ 1 , 2 ].

1. Conserved structural features and sequence patterns in the GroES fold family. Protein Eng. 12, 815-8
2. Structural classification of proteins: new superfamilies. Curr. Opin. Struct. Biol. 6, 386-94