InterPro domain: IPR013057

This transmembrane domain is found in many amino acid transporters including P34579 (UNC-47) and P40501 (MTR). UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT) and is is predicted to have 10 transmembrane domains UNC47_CAEEL [ 1 ]. MTR is an N system amino acid transporter system protein involved in methyltryptophan resistance MTR_NEUCR. Other proteins with this domain include proline transporters and amino acid transporters whose specificity has not yet been identified.

1. Identification and characterization of the vesicular GABA transporter. Nature 389, 870-6