InterPro domain: IPR012419

Cas1p protein of Cryptococcus neoformans is required for the synthesis of O-acetylated glucuronoxylomannans, a consitutent of the capsule, and is critical for its virulence [ 1 ]. The multi TM domain of the Cas1p was unified with the 10 TM Sugar Acyltransferase superfamily [ 2 ]. This superfamily is comprised of members from the OatA, MdoC, OpgC, NolL and GumG families in addition to the Cas1p family [ 3 ]. The Cas1p protein has a N-terminal PC-esterase domain with the opposing acyl esterase activity [ 3 ].

1. Cas1p is a membrane protein necessary for the O-acetylation of the Cryptococcus neoformans capsular polysaccharide. Mol. Microbiol. 42, 453-67
2. Novel eukaryotic enzymes modifying cell-surface biopolymers. Biol. Direct 5, 1