InterPro domain: IPR011304

This entry represents the NAD-dependent L-lactate dehydrogenases from bacteria and eukaryotes. This enzyme functions as the final step in anaerobic glycolysis. Although lactate dehydrogenases have in some cases been mistaken for malate dehydrogenases due to the similarity of these two substrates and the apparent ease with which evolution can toggle these activities, critical residues have been identified [ 1 ] which can discriminate between the two activities.

1. Analysis and prediction of functional sub-types from protein sequence alignments. J. Mol. Biol. 303, 61-76