InterPro domain: IPR011013

Proteins with this domain belong to the galactose mutarotase-like structural superfamily.The domain has a distorted supersandwich structure consisting of 18 strands in two sheets, and probably functions to bind carbohydrates in enzymes that act on sugars. Domains with this structure occur in several protein families, including galactose mutarotase ( 5.1.3.3 ) [ 1 ]; domain 5 of beta-galactosidase ( 3.2.1.23 ); the central domain of hyaluronate lyase-like enzymes, such as chondroitinase AC ( 4.2.2.5 ), xanthan lyase ( 4.2.2.12 ), chrondroitin ABC lyase I, and hyaluronate lyase ( 4.2.2.1 ) itself [ 2 ]; the N-terminal domain of lactobacillus maltose phosphorylase ( 2.4.1.8 ) and bacterial glucoamylase ( 3.2.1.3 ) [ 3 , 4 ]; the C-terminal domain of eukaryotic alpha-mannosidase ( 3.2.1.24 ) and archaeon 4-alpha-glucanotransferase ( 2.4.1.25 ) [ 5 ].

1. High resolution X-ray structure of galactose mutarotase from Lactococcus lactis. J. Biol. Chem. 277, 20854-61
2. Purification and characterization of hyaluronic acid from the mollusc bivalve Mytilus galloprovincialis. Biochimie 85, 619-25
3. Crystal structure of maltose phosphorylase from Lactobacillus brevis: unexpected evolutionary relationship with glucoamylases. Structure 9, 689-97
4. Glucoamylase from Thermoanaerobacterium thermosaccharolyticum: Sequence studies and analysis of the macromolecular architecture of the enzyme. J. Gen. Appl. Microbiol. 44, 327-335
5. Crystal structures of 4-alpha-glucanotransferase from Thermococcus litoralis and its complex with an inhibitor. J. Biol. Chem. 278, 19378-86