InterPro domain: IPR010770

This entry represents Ecd (ecdysoneless) family. Drosophila ecd mutants display reduced steroid titers during larval development [ 1 ]. Mammalian Ecd (also known as SGT1 and hEcd in humans) has been shown to stimulate cell proliferation by interacting with the Retinoblastoma (Rb) proteins [ 2 ]. Ecd proteins may be involved in pre-mRNA splicing [ 3 ].

Overexpression of Ecd has been linked to cancer progression [ 4 , 5 ].

1. Roles of ecdysone in Drosophila development. Proc. Natl. Acad. Sci. U.S.A. 74, 5099-103
2. Role of mammalian Ecdysoneless in cell cycle regulation. J. Biol. Chem. 284, 26402-10
3. Unexpected role of the steroid-deficiency protein ecdysoneless in pre-mRNA splicing. PLoS Genet. 10, e1004287
4. Overexpression of a novel cell cycle regulator ecdysoneless in breast cancer: a marker of poor prognosis in HER2/neu-overexpressing breast cancer patients. Breast Cancer Res. Treat. 134, 171-80
5. Overexpression of ecdysoneless in pancreatic cancer and its role in oncogenesis by regulating glycolysis. Clin. Cancer Res. 18, 6188-98