InterPro domain: IPR010237

This family of proteins includes the SDT1/SSM1 gene from yeast, which has been shown to code for a pyrimidine (UMP/CMP) 5'nucleotidase [ 1 , 2 ]. The family spans plants, fungi and bacteria. These enzymes are members of the haloacid dehalogenase (HAD) superfamily of hydrolases, specifically the IA subfamily.

1. SDT1/SSM1, a multicopy suppressor of S-II null mutant, encodes a novel pyrimidine 5'-nucleotidase. J. Biol. Chem. 277, 22103-6
2. Crystal structure of the pyrimidine 5'-nucleotidase SDT1 from Saccharomyces cerevisiae complexed with uridine 5'-monophosphate provides further insight into ligand binding. Proteins 79, 1358-62