InterPro domain: IPR009737

This entry includes proteins from fungi, plants and bacteria. Proteins in this entry contain a ferredoxin-like fold. They are predicted ferredoxins, which are iron-sulfur (Fe-S) proteins that may play a role in redox sensing and electron transfer [ 1 ]. Some members appear to have sucrolytic activity [ 2 ]. The putative active site of the ferredoxin-like domain of the enzyme contains two cysteines and two histidines for possible binding to iron-sulfur clusters, compared to four cysteines present in the active site of ferredoxin [ 3 ].

Two budding yeast proteins, Aim32 and Apd1, are included in this entry. Apd1 is an Fe-S protein and is involved in cellular defense against hydroxyurea [ 3 ]. It is required for normal localisation of actin patches in budding yeasts [ 3 ]. The function of Aim32 is not clear.

1. Loss of APD1 in yeast confers hydroxyurea sensitivity suppressed by Yap1p transcription factor. Sci Rep 5, 7897
2. Characterisation of a complementary DNA encoding a novel plant enzyme with sucrolytic activity. FEBS Lett. 354, 123-7
3. Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach. Mol. Gen. Genet. 262, 683-702