InterPro domain: IPR009637

This entry represents a group of transmembrane proteins, including mammalian lung seven transmembrane receptor GPR107 and GPR108. GPR107 localizes to the trans-Golgi network and is essential for retrograde transport [ 1 ]. This entry also includes proteins from fungi and plants [ 2 ]. The plant proteins in this entry, including CAND6 and CAND7, are predicted to be G-protein coupled receptors [ 3 ].

1. GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin. J. Biol. Chem. 289, 24005-18
2. Human GPR107 and murine Gpr108 are members of the LUSTR family of proteins found in both plants and animals, having similar topology to G-protein coupled receptors. DNA Seq. 18, 235-41
3. Whole proteome identification of plant candidate G-protein coupled receptors in Arabidopsis, rice, and poplar: computational prediction and in-vivo protein coupling. Genome Biol. 9, R120