InterPro domain: IPR008700
General Information
- Identifier IPR008700
- Description RIN4, pathogenic type III effector avirulence factor Avr cleavage site
- Number of genes 999
- Gene duplication stats Loading...
Abstract
This domain is conserved in small families of otherwise unrelated proteins in both mono-cots and di-cots, suggesting that it has a conserved, plant-specific function. It is found in the plant RIN4 (RPM1-interacting protein 4) where it appears to contribute to the binding of the protein to RCS (AvrRpt2 auto-cleavage site) and AvrB, the virulence factors from the infecting bacterium [ 1 ]. The cleavage site for the AvrRpt2 avirulence protein would appear to be the sequence motifs VPQFGDW and LPKFGEW, both of which are highly conserved within the domain [ 2 ].
1. The Pseudomonas syringae effector AvrRpt2 cleaves its C-terminally acylated target, RIN4, from Arabidopsis membranes to block RPM1 activation. Proc. Natl. Acad. Sci. U.S.A. 102, 6496-501
2. Membrane release and destabilization of Arabidopsis RIN4 following cleavage by Pseudomonas syringae AvrRpt2. Mol. Plant Microbe Interact. 18, 1258-68