InterPro domain: IPR008579

This is the conserved barrel domain of the 'cupin' superfamily found in (S)-ureidoglycine aminohydrolase (UGlyAH or UGHY) from E.coli. This enzyme is involved in the anaerobic nitrogen utilization via the assimilation of allantoin and catalyses the second stereospecific hydrolysis reaction (deamination) of the allantoin degradation pathway, producing S-ureidoglycolate and ammonia from S-ureidoglycine [ 1 , 2 ].

1. Ureide catabolism in Arabidopsis thaliana and Escherichia coli. Nat. Chem. Biol. 6, 19-21
2. Chemical basis of nitrogen recovery through the ureide pathway: formation and hydrolysis of S-ureidoglycine in plants and bacteria. ACS Chem Biol 5, 203-14