InterPro domain: IPR008551

In eukaryotes this family is predicted to play a role in protein secretion and Golgi organisation [ 1 ]. In plants this family includes A9X6Y0 , which is involved in water permeability in the cuticles of fruit [ 2 ]. P54797 has been found to be expressed during early embryogenesis in mice [ 3 ]. This protein contains a conserved NRDE motif. This gene has been characterised in Drosophila melanogaster and named as transport and Golgi organisation 2, hence the name Tango2.

1. Functional genomics reveals genes involved in protein secretion and Golgi organization. Nature 439, 604-7
2. The identification of a gene (Cwp1), silenced during Solanum evolution, which causes cuticle microfissuring and dehydration when expressed in tomato fruit. Plant J. 52, 627-39
3. Isolation of a gene expressed during early embryogenesis from the region of 22q11 commonly deleted in DiGeorge syndrome. Hum. Mol. Genet. 2, 1577-82