InterPro domain: IPR008081

This entry includes cytoplasmic fragile X mental retardation protein interacting proteins from humans and their homologues, such as Sra-1 (specifically Rac1-associated protein 1) from Drosophila and PIROGI from Arabidopsis.

In humans, there are two members, CYFIP1 and CYFIP2. They both interact with FMRP (fragile X mental retardation protein), which is responsible for pathologic manifestations in the Fragile X Syndrome. CYFIP1 interacts with the small GTPase Rac1 [ 1 , 2 ]. CYFIP1 represses cap-dependent translation of mRNA by interacting with the initiation factor eIF4E [ 3 ]. CYFIP1 and CYFIP2 are part of the Wiskott-Aldrich syndrome protein-family verprolin-homologous protein (WAVE) complex that regulates actin polymerization at synapses [ 4 ].

Drosophila Sra-1 interacts with the Kette and Wasp. It is required for neuronal and bristle development in Drosophila [ 5 ].

PIROGI is part of a WAVE complex that activates the ARP2/3 complex and is Involved in regulation of actin organization [ 6 ].

1. Reduced CYFIP1 in Human Neural Progenitors Results in Dysregulation of Schizophrenia and Epilepsy Gene Networks. PLoS ONE 11, e0148039
2. A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P. Proc. Natl. Acad. Sci. U.S.A. 98, 8844-9
3. The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell
4. Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss. Brain 134, 1042-54
5. Sra-1 interacts with Kette and Wasp and is required for neuronal and bristle development in Drosophila. Development 131, 3981-9
6. Interchangeable functions of Arabidopsis PIROGI and the human WAVE complex subunit SRA1 during leaf epidermal development. Development 131, 4345-55