InterPro domain: IPR007603
General Information
- Identifier IPR007603
- Description Choline transporter-like
- Number of genes 764
- Gene duplication stats Loading...
- Associated GO terms GO:0055085 GO:0022857
Abstract
This entry includes a group of choline transporter-like protein, including SLC44A1/2/3/4/5 from humans, Pns1 from budding yeasts, and Ctl1 from fission yeasts [ 1 ]. In humans, mutations of this family of proteins have been linked to several human diseases [ 2 ].
SLC44A1-5 are choline transporters that regulate choline transport across both the plasma membrane and the mitochondrial membrane in a Na(+)-independent manner [ 3 , 4 , 5 ].
1. Reexamining the role of choline transporter-like (Ctlp) proteins in choline transport. Neurochem. Res. 29, 461-7
2. The choline transporter-like family SLC44: properties and roles in human diseases. Mol. Aspects Med. 34, 646-54
3. The ubiquitous choline transporter SLC44A1. Cent Nerv Syst Agents Med Chem 12, 70-81
4. The solute carrier 44A1 is a mitochondrial protein and mediates choline transport. FASEB J. 23, 2749-58