InterPro domain: IPR007233

This entry includes a group of trafficking protein particle complex subunit (TRAPPC) proteins, such as TPPC1/4 from humans and Trs23/Bet5 from yeasts.

Budding yeast Trs23 and Bet5 are components of the TRAPP I, TRAPP II and TRAPP III. TRAPP complexes are guanine nucleotide exchange factors (GEF) for the GTPase Ypt1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. RAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation [ 1 , 2 , 3 ].

1. TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport. Mol. Cell 7, 433-42
2. Molecular architecture of the TRAPPII complex and implications for vesicle tethering. Nat. Struct. Mol. Biol. 17, 1298-304
3. Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy. Proc. Natl. Acad. Sci. U.S.A. 107, 7811-6