InterPro domain: IPR007033
General Information
- Identifier IPR007033
- Description RAB6-interacting golgin
- Number of genes 534
- Gene duplication stats Loading...
Abstract
This entry represents RAB6-interacting golgin, including SCYL1BP1 (also known as GORAB) from humans. SCYL1BP1 localises to the Golgi apparatus and interacts with Rab6 [ 1 , 2 ]. Therefore, SCYL1BP1 is identified as a golgin, a protein that tether vesicles to the Golgi apparatus.
This entry also includes plant proteins, such as TaSRG ( F4MH09 ) from wheat. TaSRG plays a role in stress response in plants [ 3 ].
1. Gerodermia osteodysplastica is caused by mutations in SCYL1BP1, a Rab-6 interacting golgin. Nat. Genet. 40, 1410-2
2. GORAB Missense Mutations Disrupt RAB6 and ARF5 Binding and Golgi Targeting. J. Invest. Dermatol.
3. TaSRG, a wheat transcription factor, significantly affects salt tolerance in transgenic rice and Arabidopsis. FEBS Lett. 585, 1231-7