InterPro domain: IPR006676
General Information
- Identifier IPR006676
- Description tRNA-splicing endonuclease
- Number of genes 179
- Gene duplication stats Loading...
- Associated GO terms GO:0006388 GO:0000213
Abstract
tRNA-splicing endonucleases ( 3.1.27.9 ) catalyse the endonucleolytic cleavage of pre tRNA at the 5' and 3' splice sites to release the intron and produces two half tRNA molecules bearing 5' hydroxyl and 2', 3'-cyclic phosphate termini [ 1 , 2 ]. The genes encoding these proteins are homologous in eukaryotes and archea. The eukaryotic tRNA-splicing endonucleases are heterotetrameric while the archaeal endonucleases can be split into homodimeric and homotetrameric subgroups.
1. RNA-protein interactions of an archaeal homotetrameric splicing endoribonuclease with an exceptional evolutionary history. EMBO J. 16, 6290-300
2. The yeast tRNA splicing endonuclease: a tetrameric enzyme with two active site subunits homologous to the archaeal tRNA endonucleases. Cell 89, 849-58