InterPro domain: IPR006461

This entry represents a group of cys-rich proteins, including cornifelin and PLAC8 from animals, MCA (MID1-COMPLEMENTING ACTIVITY) and PCR (PLANT CADMIUM RESISTANCE) from Arabidopsis and cell number regulators from maize [ 1 , 2 ].

Cornifelin is part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia [ 3 , 4 ]. PLAC8 is required for white adipocyte differentiation in vitro and cell number control in vivo [ 5 ].

Plant transports in this entry include MCA1, MCA2 and PCR1-12. MCA1 and MCA2 mediate Ca2+ uptake [ 6 , 7 , 8 ], while PCR2 is a zinc exporter involved in both zinc extrusion and long-distance zinc transport [ 9 ].

1. Cell Number Regulator1 affects plant and organ size in maize: implications for crop yield enhancement and heterosis. Plant Cell 7, e48767
2. Common functions or only phylogenetically related? The large family of PLAC8 motif-containing/PCR genes. Mol. Cells
3. Identification and characterization of a novel component of the cornified envelope, cornifelin. Biochem. Biophys. Res. Commun. 318, 803-13
4. Identification of cornifelin and early growth response-1 gene as novel biomarkers for in vitro eye irritation using a 3D reconstructed human cornea model MCTT HCEâ„¢ Arch. Toxicol. 9, e87724
5. Plac8 is required for white adipocyte differentiation in vitro and cell number control in vivo. PLoS ONE 52, 1915-30
6. MCA1 and MCA2 that mediate Ca2+ uptake have distinct and overlapping roles in Arabidopsis. Plant Physiol. 152, 1284-96
7. Structural characterization of the mechanosensitive channel candidate MCA2 from Arabidopsis thaliana. PLoS ONE 22, 1057-73
8. Determination of structural regions important for Ca(2+) uptake activity in Arabidopsis MCA1 and MCA2 expressed in yeast. Plant Cell Physiol. 31, 1-7
9. Arabidopsis PCR2 is a zinc exporter involved in both zinc extrusion and long-distance zinc transport. Plant Cell 22, 2237-52