InterPro domain: IPR006266

This entry represents the UMP-CMP kinase subfamily of the adenylate kinase family. UMP-CMP kinase catalyses the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP and is involved in de novo pyrimidine nucleotide biosynthesis [ 1 , 2 ]. In budding yeast, it is also known as Ura6 [ 3 ].

1. Functional analysis of pyrimidine biosynthesis enzymes using the anticancer drug 5-fluorouracil in Caenorhabditis elegans. FEBS J. 276, 4715-26
2. Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. Cancer Res. 62, 1624-31
3. The adenylate kinase family in yeast: identification of URA6 as a multicopy suppressor of deficiency in major AMP kinase. Gene 122, 111-8