InterPro domain: IPR006139

General Information

  • Identifier IPR006139
  • Description D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
  • Number of genes 1366
  • Gene duplication stats Loading...
  • Associated GO terms GO:0016616   GO:0051287  

Abstract

A number of NAD-dependent 2-hydroxyacid dehydrogenases which seem to be specific for the D-isomer of their substrate have been shown to be functionally and structurally related. The catalytic domain contains a number of conserved charged residues which may play a role in the catalytic mechanism [ 1 ]. The NAD-binding domain is described in IPR006140 .


1. Crystal structure of a ternary complex of D-2-hydroxyisocaproate dehydrogenase from Lactobacillus casei, NAD+ and 2-oxoisocaproate at 1.9 A resolution. J. Mol. Biol. 267, 640-60

Species distribution

Gene table