InterPro domain: IPR005215
General Information
- Identifier IPR005215
- Description Trigger factor
- Number of genes 301
- Gene duplication stats Loading...
- Associated GO terms GO:0015031
Abstract
The trigger factor is found in several prokaryotes, and is involved in protein export. Trigger factor is a ribosome-associated molecular chaperone and is the first chaperone to interact with nascent polypeptide. It acts as a chaperone by maintaining the newly synthesised protein in an open conformation. Trigger factor can bind at the same time as the signal recognition particle (SRP), but is excluded by the SRP receptor (FtsY). The central domain of trigger factor has peptidyl-prolyl cis/trans isomerase activity [ 1 ].
The trigger factor-like protein included in this entry can be found in plant chloroplasts, where it may be involved in protein export.
1. Functional dissection of Escherichia coli trigger factor: unraveling the function of individual domains. J. Bacteriol. 186, 3777-84