InterPro domain: IPR005181

General Information

  • Identifier IPR005181
  • Description Sialate O-acetylesterase domain
  • Number of genes 516
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Abstract

This entry represents a domain found in eukaryotic sialic acid acetylesterases (SIAEs). The catalytic triad of this esterase enzyme comprises residues Ser127, His403 and Asp391 in mouse SIAE [ 1 , 2 ]. Proteins containing this domain also include some uncharacterised bacterial proteins.


1. The structure at 1.6 Angstroms resolution of the protein product of the At4g34215 gene from Arabidopsis thaliana. Acta Crystallogr. D Biol. Crystallogr. 61, 1655-61
2. Functionally defective germline variants of sialic acid acetylesterase in autoimmunity. Nature 466, 243-7

Species distribution

Gene table