InterPro domain: IPR005061
General Information
- Identifier IPR005061
- Description Vacuolar protein sorting-associated protein Ist1
- Number of genes 1454
- Gene duplication stats Loading...
- Associated GO terms GO:0015031
Abstract
Budding yeast Ist1 is involved in a late step in sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles [ 1 ]. This entry also includes Ist1 homologues from animals and plants. Human Ist1 functions in the ESCRT (endosomal sorting complexes required for transport) pathway and is required for efficient abscission during HeLa cell cytokinesis [ 2 ]. Human Ist1 binds the transport (MIT) domain of VPS4, LIP5, and Spartin via its C-terminal MIT-interacting motif (MIM) [ 3 ].
1. Novel Ist1-Did2 complex functions at a late step in multivesicular body sorting. Mol. Biol. Cell 19, 475-84
2. Biochemical analyses of human IST1 and its function in cytokinesis. Mol. Biol. Cell 20, 1360-73
3. Distinct mechanisms of recognizing endosomal sorting complex required for transport III (ESCRT-III) protein IST1 by different microtubule interacting and trafficking (MIT) domains. J. Biol. Chem. 290, 8396-408